Implantable micro-optical semiconductor devices for optical theranostics in deep tissue. (3rd March 2016)

• Record Type: Journal Article
• Authors: Takehara, Hiroaki; Katsuragi, Yuji; Ohta, Yasumi; Motoyama, Mayumi; Takehara, Hironari; Noda, Toshihiko; Sasagawa, Kiyotaka; Tokuda, Takashi; Ohta, Jun
• Is Part Of: Applied physics express. Volume 9:Number 4(2016:Apr.)
• Publication Date: 2016-03-03
• Subjects: Physics -- Periodicals; Technology -- Periodicals; 621.05
• DOI: 10.7567/APEX.9.047001
• Languages: English
• ISSNs: 1882-0778

Abstract

Abstract: Optical therapy and diagnostics using photoactivatable molecular tools are promising approaches in medical applications; however, a method for the delivery of light deep inside biological tissues remains a challenge. Here, we present a method of illumination and detection of light using implantable micro-optical semiconductor devices. Unlike in conventional transdermal light delivery methods using low-energy light (>620 nm or near-infrared light), in our method, high-energy light (470 nm) can also be used for illumination. Implanted submillimeter-sized light-emitting diodes were found to provide sufficient illumination (0.6–4.1 mW/cm 2 ), and a complementary metal–oxide–semiconductor image sensor enabled the detection of fluorescence signals.