Triacylglycerol metabolism in adipose tissue. (April 2007)

• Record Type: Journal Article
• Authors: Ahmadian, Maryam; E Duncan, Robin; Jaworski, Kathy; Sarkadi-Nagy, Eszter; Sul, Hei Sook
• Is Part Of: Future lipidology. Volume 2:Number 2(2007)
• Page Start: 229
• Page End: 237
• Publication Date: 2007-04
• Subjects: 1-acylglycerol-3-phosphate acyltransferase -- desnutrin/adipose triglyceride lipase -- diacylglycerol acyltransferase -- glycerol-3-phosphate acyltransferase -- hormone-sensitive lipase -- lipolysis -- phosphatidic acid phosphatase -- triacylglycerol; Lipids -- Periodicals; 616.3997
• DOI: 10.2217/17460875.2.2.229
• Languages: English
• ISSNs: 1746-0875

Abstract

Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem. Understanding of adipocyte-specific TAG synthesis and hydrolysis is critical to the development of strategies to treat and prevent obesity and its closely associated diseases, for example, Type 2 diabetes, hypertension and atherosclerosis. In this review, we present an overview of the major enzymes in TAG synthesis and lipolysis, including the recent discovery of a novel adipocyte TAG hydrolase.