Clinical use of organic near‐infrared fluorescent contrast agents in image‐guided oncologic procedures and its potential in veterinary oncology. (22nd September 2018)

• Record Type: Journal Article
• Authors: Favril, Sophie; Abma, Eline; Blasi, Francesco; Stock, Emmelie; Devriendt, Nausikaa; Vanderperren, Katrien; de Rooster, Hilde
• Is Part Of: Veterinary record. Volume 183:Number 11(2018)
• Page Start: 354
• Page End: 354
• Publication Date: 2018-09-22
• Subjects: Near‐infrared fluorescence imaging -- organic near‐infrared fluorescent contrast agents -- guided oncologic surgery -- comparative oncology -- sentinel lymph node mapping; Veterinary medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Veterinary medicine; Veterinary Medicine; Periodicals; Periodical; Electronic journals; 636.089
• DOI: 10.1136/vr.104851
• Languages: English
• ISSNs: 0042-4900

Abstract

Abstract : One of the major challenges in surgical oncology is the intraoperative discrimination of tumoural versus healthy tissue. Until today, surgeons rely on visual inspection and palpation to define the tumoural margins during surgery and, unfortunately, for various cancer types, the local recurrence rate thus remains unacceptably high. Near‐infrared (NIR) fluorescence imaging is an optical imaging technique that can provide real‐time preoperative and intraoperative information after administration of a fluorescent probe that emits NIR light once exposed to a NIR light source. This technique is safe, cost‐effective and technically easy. Several NIR fluorescent probes are currently studied for their ability to highlight neoplastic cells. In addition, NIR fluorescence imaging holds great promise for sentinel lymph node mapping. The aim of this manuscript is to provide a literature review of the current organic NIR fluorescent probes tested in the light of human oncology and to introduce fluorescence imaging as a valuable asset in veterinary oncology.