Developments in virus-like particle-based vaccines for HIV. (February 2013)

• Record Type: Journal Article
• Authors: Buonaguro, Luigi; Tagliamonte, Maria; Visciano, Maria Luisa; Tornesello, Maria Lina; Buonaguro, Franco M
• Is Part Of: Expert review of vaccines. Volume 12:Number 2(2013)
• Page Start: 119
• Page End: 127
• Publication Date: 2013-02
• Subjects: baculovirus expression vector system -- broadly neutralizing antibody -- conformational antigen presentation -- HIV-VLPs -- insect cells stable expression -- vaccines; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1586/erv.12.152
• Languages: English
• ISSNs: 1476-0584

Abstract

Virus-like particles (VLPs) hold great promise for the development of effective and affordable vaccines. VLPs, indeed, are suitable for presentation and efficient delivery to antigen-presenting cells of linear as well as conformational antigens. This will ultimately result in a crosspresentation with both MHC class I and II molecules to prime CD4 + T-helper and CD8 + cytotoxic T cells. This review describes an update on the development and use of VLPs as vaccine approaches for HIV.