Superparamagnetic iron oxide-enhanced MRI at 3 T for accurate axillary staging in breast cancer. Issue 1 (17th November 2015)

• Record Type: Journal Article
• Authors: Motomura, K; Izumi, T; Tateishi, S; Tamaki, Y; Ito, Y; Horinouchi, T; Nakanishi, K
• Is Part Of: British journal of surgery. Volume 103:Issue 1(2016)
• Page Start: 60
• Page End: 69
• Publication Date: 2015-11-17
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1002/bjs.10040
• Languages: English
• ISSNs: 0007-1323

Abstract

Abstract: Background: The aim of this study was to evaluate whether MRI at 3 T with superparamagnetic iron oxide (SPIO) enhancement is an accurate and useful method for detecting metastases in sentinel nodes identified by CT-lymphography (CT-LG) in patients with breast cancer. The results were compared with those obtained using CT-LG alone and diagnosing metastasis according to size criteria. Methods: Patients with clinically node-negative breast cancer were included. Sentinel nodes identified by CT-LG were evaluated prospectively using SPIO-enhanced MRI at 3 T. Sentinel node size was measured on CT-LG, and a node larger than 5 mm in short-axis diameter was considered metastatic. Sentinel nodes localized by CT-LG were removed, and imaging results and histopathological findings were compared. Results: Sentinel nodes were identified successfully by CT-LG in 69 (99 per cent) of 70 patients. All 19 patients with a finding of metastasis in sentinel nodes at pathology were also shown to have metastases on MRI. Forty-eight of 50 patients with non-metastatic sentinel nodes diagnosed at pathology were classified as having non-metastatic nodes on MRI. On a patient-by-patient basis, the sensitivity, specificity and accuracy of MRI for the diagnosis of sentinel node metastases were 100, 96 and 97 per cent; respective values for CT-LG were 79, 56 and 62 per cent. The specificity and accuracy of MRI were superior to those of CT-LG ( P < 0·001 and P = 0·002 respectively). Conclusion: SPIO-enhanced MRI at 3 T is useful for accurate diagnosis of metastatic sentinel nodes, indicating that sentinel node biopsy may be avoided in patients with breast cancer who have non-metastatic sentinel nodes on imaging. Abstract : Imaging replaces sentinel node biopsy