Rh(III)‐Catalyzed Regioselective Acetylation of sp2 C−H Bond Starting from Paraformaldehyde. Issue 16 (20th February 2019)

• Record Type: Journal Article
• Authors: Wan, Ting; Du, Sidong; Pi, Chao; Wang, Yong; Li, Rongbin; Wu, Yangjie; Cui, Xiuling
• Is Part Of: ChemCatChem. Volume 11:Issue 16(2019)
• Page Start: 3791
• Page End: 3796
• Publication Date: 2019-02-20
• Subjects: C−H activation -- acylation -- rhodium-catalyzed -- paraformaldehyde -- one-pot manner; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201801512
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract: Rh(III)‐catalyzed acetylation of sp 2 C−H bonds has been realized using paraformaldehyde as an acetylating reagent. This procedure features simultaneous formation of two C−C bonds, external oxidants free, and water as the sole byproducts, thus offering an environmentally benign acetylation of arenes. A range of functional groups tolerance were observed. Abstract : Ride the rhodacycle : Rh(III)‐catalyzed regioselective acetylation of arenes using paraformaldehyde as a novel acetyl reagent, which may undergo twice insertion of aldehyde and form two C−C bonds in one‐pot manner. This protocol proceeded smoothly under air atmosphere, avoided external oxidants, and produced water as the sole byproduct.