Α‐Arylation of Carbonyl Compounds through Oxidative C−C Bond Activation. Issue 29 (6th June 2019)

• Record Type: Journal Article
• Authors: Li, Jing; Bauer, Adriano; Di Mauro, Giovanni; Maulide, Nuno
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 29(2019)
• Page Start: 9816
• Page End: 9819
• Publication Date: 2019-06-06
• Subjects: arylation -- C−C bond activation -- enolonium species -- ketones -- umpolung; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201904899
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: A synthetically useful approach for the direct α‐arylation of carbonyl compounds through a novel oxidative C−C bond activation is reported. This mechanistically unusual process relies on a 1, 2‐aryl shift and results in all‐carbon quaternary centers. The transformation displays broad functional‐group tolerance and can in principle also be applied as an asymmetric variant. Abstract : Activate and arylate : A synthetically useful approach for the direct α‐arylation of carbonyl compounds through a novel oxidative C−C bond activation is reported. This mechanistically unusual process relies on a 1, 2‐aryl shift and results in all‐carbon quaternary centers. The transformation displays broad functional‐group tolerance and can in principle also be applied as an asymmetric variant.