Front Cover: Deracemization in a Complex Quaternary System with a Second‐Order Asymmetric Transformation by Using Phase Diagram Studies (Chem. Eur. J. 61/2019). Issue 61 (20th September 2019)

• Record Type: Journal Article
• Authors: Oketani, Ryusei; Marin, Francesco; Tinnemans, Paul; Hoquante, Marine; Laurent, Anne; Brandel, Clément; Cardinael, Pascal; Meekes, Hugo; Vlieg, Elias; Geerts, Yves; Coquerel, Gérard
• Is Part Of: Chemistry. Volume 25:Issue 61(2019)
• Page Start: 13833
• Page End: 13833
• Publication Date: 2019-09-20
• Subjects: atropisomerism -- chiral resolution -- deracemization -- phase diagrams -- second-order asymmetric transformation; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201904003
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Phase diagrams play a critical role for tuning crystallization. This study explains the basics of phase diagrams starting from the ternary system to a quaternary system with and without fast racemization in the liquid phase. Experimentally, an atropisomeric naphthamide derivative in MeOH/H2 O serves as an example. Deracemization is ensured by a second‐order asymmetric transformation up to 97% ee . Readers are encouraged to look at the animation (in the Supporting Information) detailing the construction of the degenerated quaternary system in a step‐by‐step manner. More information can be found in the Full Paper by G. Coquerel et al. on page 13890 .