Back Cover: Unidirectional Presentation of Membrane Proteins in Nanoparticle‐Supported Liposomes (Angew. Chem. Int. Ed. 29/2019). Issue 29 (25th June 2019)

• Record Type: Journal Article
• Authors: Chen, Wen; Cai, Yongfei; Fu, Qingshan; Chen, Bing; Guo, Junling; Chou, James J.
• Is Part Of: Angewandte Chemie international edition. Volume 58:Issue 29(2019)
• Page Start: 90010
• Page End: 90010
• Publication Date: 2019-06-25
• Subjects: HIV-1 MPER -- membrane antigen presentation -- nanoparticles -- proteoliposome formation -- unidirectionality; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201907302
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Presentation of membrane proteins to host immune systems in a conformation‐specific manner is a major challenge in vaccine or antibody development. In their Communication on page 9866 ff., J. Guo, J. J. Chou, et al. developed a method to address this challenge. They used a functionalized nanoparticle as a substrate to guide the formation of proteoliposome that can unidirectionally present many copies of membrane proteins.