Inside Cover: Regioselective Metal‐ and Reagent‐Free Arylation of Benzothiophenes by Dehydrogenative Electrosynthesis (Angew. Chem. Int. Ed. 40/2018). Issue 40 (19th September 2018)

• Record Type: Journal Article
• Authors: Lips, Sebastian; Schollmeyer, Dieter; Franke, Robert; Waldvogel, Siegfried R.
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 40(2018)
• Page Start: 12980
• Page End: 12980
• Publication Date: 2018-09-19
• Subjects: arylation -- C−C coupling -- electrochemistry -- oxidation -- sulfur heterocycles; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201810303
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : Electrochemical "welding" serves as a powerful tool for the arylation of benzo[ b ]thiophenes in position 2 or 3. S. R. Waldvogel and co‐workers report in their Communication on page 13325 ff. the first electro‐organic dehydrogenative synthesis of 2‐ or 3‐(hydroxyphenyl)benzo[ b ]thiophenes by oxidative cross‐coupling reactions. The direct use of electricity as a reagent eliminates the necessity of leaving groups, metal catalysts, stoichiometric oxidizers, or reducing agents. Therefore, the reaction enables a sustainable synthetic pathway to these scaffolds and can be considered as "green chemistry".