Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin. Issue 6 (7th February 2018)

• Record Type: Journal Article
• Authors: Delhorme, J-B; Severac, F; Averous, G; Glehen, O; Passot, G; Bakrin, N; Marchal, F; Pocard, M; Lo Dico, R; Eveno, C; Carrere, S; Sgarbura, O; Quenet, F; Ferron, G; Goéré, D; Brigand, C; Abba, J; Abboud, K; Alyami, M; Arvieux, C; Averous, G; Bakrin, N; Balagué, G; Barrau, V; Ben Rejeb, H; Bereder, J-M; Berton-Rigaud, I; Bibeau, F; Bonnefoy, I; Bouzard, D; Bricault, I; Brigand, C; Carrère, S; de Chaisemartin, C; Chassang, M; Chevallier, A; Courvoisier, T; Dartigues, P; Dohan, A; Dubreuil, J; Dumont, F; Eveno, C; Faruch-Bilfeld, M; Ferron, G; Fontaine, J; Fournier, L; Gagniere, J; Geffroy, D; Ghouti, L; Gilly, F-N; Gladieff, L; Glehen, O; Goéré, D; Guibal, A; Guilloit, J-M; Guyon, F; Heyd, B; Hoeffel, C; Hordonneau, C; Isaac, S; Jourdan-Enfer, P; Kaci, R; Kianmanesh, R; Labbé-Devilliers, C; Lacroix, J; Lelong, B; Leroux-Broussier, A; Lherm, Y; Lo Dico, R; Lorimier, G; Malhaire, C; Marchal, F; Mariani, P; Mathiotte, E; Meeus, P; Mery, E; Msika, S; Nadeau, C; Ortega-Deballon, P; Passot, G; Pellet, O; Peyrat, P; Pezet, D; Pirro, N; Pocard, M; Poizat, F; Porcheron, J; Poulet, A; Quenet, F; Rat, P; Rousselot, P; Rousset, P; Senellart, H; Serrano, M; Servois, V; Sgabura, O; Skanjeti, A; Svrcek, M; Tetreau, R; Thibaudeau, E; Touchefeu, Y; Tuech, J-J; Valmary-Degano, S; Vaudoyer, D; Velasco, S; Verriele-Beurrier, V; Villeneuve, L; Wernert, R; Zinzindohoue, F;
• Is Part Of: British journal of surgery. Volume 105:Issue 6(2018)
• Page Start: 668
• Page End: 676
• Publication Date: 2018-02-07
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1002/bjs.10716
• Languages: English
• ISSNs: 0007-1323

Abstract

Abstract: Background: The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Methods: All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database. Patients with EA-PMP had pathologically confirmed non-neoplastic appendices and were matched in a 1 : 4 ratio with patients treated for appendicular PMP (A-PMP), based on a propensity score. Results: Some 726 patients were identified, of which 61 (EA-PMP group) were matched with 244 patients (A-PMP group). The origins of primary tumours in the EA-PMP group included the ovary (45 patients), colon (4), urachus (4), small bowel (1), pancreas (1) and unknown (6). The median peritoneal carcinomatosis index was comparable in EA-PMP and A-PMP groups (15·5 versus 18 respectively; P = 0·315). In-hospital mortality (3 versus 2·9 per cent; P = 1·000) and major morbidity 26 versus 25·0 per cent; P = 0·869) were also similar between the two groups. Median follow-up was 66·9 months. The 5-year overall survival rate was 87·8 (95 per cent c.i. 83·2 to 92·5) per cent in the A-PMP group and 87 (77 to 96) per cent in the EA-PMP group. The 5-year disease-free survival rate was 66·0 (58·7 to 73·4) per cent and 70 (53 to 83) per cent respectively. Conclusion: Overall and disease-free survival following treatment with CCRS and HIPEC is similar in patients with pseudomyxoma peritonei of appendicular or extra-appendicular origin. Abstract : Survival similar