Assessment and validation of a novel angiographic scoring system for peripheral artery disease. Issue 5 (31st January 2017)

• Record Type: Journal Article
• Authors: Morris, D R; Singh, T P; Moxon, J V; Smith, A; Stewart, F; Jones, R E; Golledge, J
• Is Part Of: British journal of surgery. Volume 104:Issue 5(2017)
• Page Start: 544
• Page End: 554
• Publication Date: 2017-01-31
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1002/bjs.10460
• Languages: English
• ISSNs: 0007-1323

Abstract

Abstract: Background: Angiography is used routinely in the assessment of lower-limb arteries, but there are few well validated angiographic scoring systems. The aim of this study was to develop and validate a novel angiographic scoring system for peripheral artery disease. Methods: An angiographic scoring system (the ANGIO score) was developed and applied to a sample of patients from a single vascular surgical department who underwent CT angiography of the lower limbs. The reproducibility of the ANGIO score was compared with those of the Bollinger and Trans-Atlantic inter-Society Consensus (TASC) IIb systems in a series of randomly selected patients. Associations between the ANGIO score and lower-limb ischaemia, as measured by the ankle : brachial pressure index (ABPI), and outcome events (major lower-limb amputations and cardiovascular events – myocardial infarction, stroke and cardiovascular death) were assessed. Results: Some 256 patients undergoing CT angiography were included. The interobserver reproducibility of the ANGIO score was better than that of the other scoring systems examined (κ = 0·90, P = 0·002). There was a negative correlation between the ANGIO score and ABPI (ρ = −0·33, P = 0·008). A higher ANGIO score was associated with an increased risk of major lower-limb amputation (hazard ratio (HR) for highest versus lowest tertile 9·30, 95 per cent c.i. 1·95 to 44·38; P = 0·005) and cardiovascular events (HR 2·73, 1·31 to 5·70; P = 0·007) following adjustment for established risk factors. Conclusion: The ANGIO score provided a reproducible and valid assessment of the severity of lower-limb ischaemia and risk of major amputation and cardiovascular events in these patients with peripheral artery disease. Abstract : Wider validation necessary