Pathogenesis guided therapeutic management of COVID-19: an immunological perspective. (4th March 2021)

• Record Type: Journal Article
• Authors: Kumar, Ashutosh; Prasoon, Pranav; Sekhawat, Prakash S.; Pareek, Vikas; Faiq, Muneeb A.; Kumari, Chiman; Narayan, Ravi K.; Kulandhasamy, Maheswari; Kant, Kamla
• Is Part Of: International reviews of immunology. Volume 40:Number 1/2(2021)
• Page Start: 54
• Page End: 71
• Publication Date: 2021-03-04
• Subjects: Anti-virals -- betacoronaviruses -- immunopathogenesis -- SARS-CoV-2 -- therapeutic strategy; Immunology -- Periodicals; Autoimmune diseases -- Periodicals; 616.079
• DOI: 10.1080/08830185.2020.1840566
• Languages: English
• ISSNs: 0883-0185

Abstract

Abstract: Lack of standardized therapeutic approaches is arguably the significant contributor to the high burden of mortality observed in the ongoing pandemic of the Coronavirus disease, 2019 (COVID-19). Evidence is accumulating on SARS-CoV-2 specific immune cell dysregulation and consequent tissue injury in COVID-19. Currently, no definite drugs or vaccines are available against the disease; however initial results of the ongoing clinical trials have raised some hope. In this article, taking insights from the emerging empirical evidence about host-virus interactions, we deliberate upon plausible pathogenic mechanisms and suitable therapeutic approaches for COVID-19.