Treatment of PERItoneal disease in Stomach Cancer with cytOreductive surgery and hyperthermic intraPEritoneal chemotherapy: PERISCOPE I initial results. Issue 11 (11th April 2020)

• Record Type: Journal Article
• Authors: Kaaij, R T; Wassenaar, E C E; Koemans, W J; Sikorska, K; Grootscholten, C; Los, M; Huitema, A; Schellens, J H M; Veenhof, A A F A; Hartemink, K J; Aalbers, A G J; Ramshorst, B; Boerma, D; Boot, H; Sandick, J W
• Is Part Of: British journal of surgery. Volume 107:Issue 11(2020)
• Page Start: 1520
• Page End: 1528
• Publication Date: 2020-04-11
• Subjects: Surgery -- Periodicals; 617.005
• DOI: 10.1002/bjs.11588
• Languages: English
• ISSNs: 0007-1323

Abstract

Abstract: Background: The role of cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in gastric cancer is unknown. This non-randomized dose-finding phase I–II study was designed to assess the safety and feasibility of HIPEC, following systemic chemotherapy, in patients with gastric cancer and limited peritoneal dissemination. The maximum tolerated dose of normothermic intraperitoneal docetaxel in combination with a fixed dose of intraperitoneal oxaliplatin was also explored. Methods: Patients with resectable cT3–cT4a gastric adenocarcinoma with limited peritoneal metastases and/or tumour-positive peritoneal cytology were included. An open HIPEC technique was used with 460 mg/m 2 hyperthermic oxaliplatin for 30 min followed by normothermic docetaxel for 90 min in escalating doses (0, 50, 75 mg/m 2 ). Results: Between 2014 and 2017, 37 patients were included. Of 25 patients who completed the full study protocol, four were treated at dose level 1 (0 mg/m 2 docetaxel), six at dose level 2 (50 mg/m 2 ) and four at dose level 3 (75 mg/m 2 ). At dose level 3, two dose-limiting toxicities occurred, both associated with postoperative ileus. Thereafter, another 11 patients were treated at dose level 2, with no more dose-limiting toxicities. Based on this, the maximum tolerated dose was 50 mg/m 2 intraperitoneal docetaxel. Serious adverse events were scored in 17 of 25 patients. The reoperation rate was 16 per cent (4 of 25) and the treatment-related mortality rate was 8 per cent (2 patients, both in dose level 3). Conclusion: Gastrectomy combined with cytoreductive surgery and HIPEC was feasible using 460 mg/m 2 oxaliplatin and 50 mg/m 2 normothermic docetaxel. Graphical Abstract: The PERISCOPE I study was a dose-finding phase I–II study exploring the feasibility of gastrectomy combined with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in patients with limited peritoneal dissemination from gastric cancer. The procedure was feasible, with an intraperitoneal dose of 460 mg/m 2 oxaliplatin at 41–42°C, followed by 50 mg/m 2 docetaxel at 37°C. Feasible