Benign and malignant apocrine lesions of the breast. Issue 2 (February 2012)

• Record Type: Journal Article
• Authors: Gerhard, Renê; Costa, José Luis; Schmitt, Fernando
• Is Part Of: Expert review of anticancer therapy. Volume 12:Issue 2(2012)
• Page Start: 215
• Page End: 221
• Publication Date: 2012-02
• Subjects: androgen -- apocrine -- breast -- carcinoma -- histological subtype; Cancer -- Treatment -- Periodicals; 616.99406
• DOI: 10.1586/era.11.213
• Languages: English
• ISSNs: 1473-7140

Abstract

Apocrine differentiation occurs in a variety of breast lesions, both benign and malignant. This review is a reflection of our critical view of the recent advances towards the understanding of this particular type of breast lesions. Focus is given to the histological criteria that allow their reproductive identification, with additional attention to the recent microarray studies. These describe the recent molecular classification of breast cancer and identify an apocrine molecular subtype that opens the door for new putative therapies for this particular type of tumor. Indeed we anticipate that the determination of androgen receptor will enter into the routine assessment of breast cancer cases and become a surrogate marker for treatment in apocrine triple-negative breast cancer.