Diagnosis and treatment of adenovirus infection in immunocompromised patients. Issue 10 (October 2013)

• Record Type: Journal Article
• Authors: Matthes-Martin, Susanne; Boztug, Heidrun; Lion, Thomas
• Is Part Of: Expert review of anti-infective therapy. Volume 11:Issue 10(2013)
• Page Start: 1017
• Page End: 1028
• Publication Date: 2013-10
• Subjects: adenovirus -- chemotherapy -- cidofovir -- CMX001 -- immunocompromised patients -- organ transplantation -- stem cell transplantation -- viral infection -- virus-specific T cells; Anti-infective agents -- Research -- Periodicals; 616.90461
• DOI: 10.1586/14787210.2013.836964
• Languages: English
• ISSNs: 1478-7210

Abstract

In immunocompromised patients, human adenovirus (HAdV) infections can cause life-threatening multiorgan disease. This review summarizes the incidence and risk factors of invasive human adenovirus infections in immunocompromised patients as well as the recently developed standards for diagnostic methods and strategies according to the predominant risk factors in adults and children. Recommendations for preemptive and therapeutic treatment strategies and the outcome in different risk groups are presented. Novel therapeutic approaches including CMX001, a new orally bioavailable lipid conjugate of cidofovir and the transfer of adenovirus-specific donor T cells in the context of allogeneic stem cell transplantation are discussed.