Chronic rhinosinusitis and age: is the pathogenesis different?. Issue 10 (October 2013)

• Record Type: Journal Article
• Authors: Mahdavinia, Mahboobeh; Grammer, Leslie C
• Is Part Of: Expert review of anti-infective therapy. Volume 11:Issue 10(2013)
• Page Start: 1029
• Page End: 1040
• Publication Date: 2013-10
• Subjects: adults -- bacteriology -- chronic rhinosinusitis -- elderly -- histopathology -- immunodeficiency -- nasal polyps -- pediatrics; Anti-infective agents -- Research -- Periodicals; 616.90461
• DOI: 10.1586/14787210.2013.839380
• Languages: English
• ISSNs: 1478-7210

Abstract

Chronic rhinosinusitis (CRS) is a common disease with a significant impact on quality of life, which is seen across all age groups. There are differences in symptomatology, histopathology and associated diseases when comparing pediatric versus adult patients with CRS. Nasal polyposis tends to be less commonly seen in pediatric CRS compared with adults except in children with cystic fibrosis or allergic fungal rhinosinusitis. The differences in histopathology of CRS in different age groups include higher cellularity and more prominent lymphocytic infiltration in children compared with adults who tend to have a stronger eosinophilic infiltration and more prominent glandular hyperplasia. There are data supporting a stronger association of gastroesophageal reflux disease and otitis media with CRS in children compared with adults. Adenoids may play a role in pediatric, but not adult CRS. Immunodeficiencies and asthma are strongly associated with CRS in all age groups. There is a paucity of data on pathophysiology of disease on elderly CRS.