Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols. (2010)

• Record Type: Journal Article
• Authors: Reis Corrales, Roberta Novaes; Pinheiro, Liliane Sena; Coimbra, Elaine Soares; Da Silva, Adilson David; Le Hyaric, Mireille
• Other Names: Cos Paul Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 10(2010)
• Page Start: 1067
• Page End: 1072
• Publication Date: 2010
• Subjects: aminoalcohols -- antileishmanial activity -- Leishmania -- polyamines; Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2010.106
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : In this work, we report on the preparation and evaluation of the in vitro antileishmanial activity of a series of lipophilic aromatic aminoalcohols. All compounds were assessed for their in vitro activity against promastigotes of three Leishmania species The most lipophilic aminoalcohols bearing an aliphatic moiety with eight to 12 carbon atoms displayed a good activity against L. amazonensis and L. major, and two of them also showed antiproliferative activity against L. chagasi . The best results were obtained for the N-dodecanoyl ethylenediamine derivative and for N-decyl aminoalcohol (IC50 = 5.2 and 0.7 μ M, respectively).