Phosphatidic acid: Mono- and poly-unsaturated forms regulate distinct stages of neuroendocrine exocytosis. (January 2021)

• Record Type: Journal Article
• Authors: Tanguy, Emeline; Wolf, Alexander; Montero-Hadjadje, Maité; Gasman, Stéphane; Bader, Marie-France; Vitale, Nicolas
• Is Part Of: Advances in biological regulation. Volume 79(2021)
• Publication Date: 2021-01
• Subjects: Exocytosis -- Fatty acid -- Phosphatidic acid -- Phospholipase D -- Neuroendocrine secretion; ADR Acyldihydroxyacetone-phosphate reductase -- CDP Cytidyl phosphatidate -- CDS CDP-diacylglycerol synthase -- CgA Chromogranine A -- CL Cardiolipin -- DAG Diacyglycerol -- DGK Diacylglycerol kinase -- DHAP Dihydroxyacetone phosphate -- DHAP AT DHAP acyltransferase -- FIPI 5-Fluoro-2-indolyl des-chlorohalopemide -- G3P Glycerol 3-phosphate -- GPAT G3P acyltransferase -- LPA Lysophosphatidic acid -- LPAAT Lysophosphatidic acid-acyltransferases -- PA Phosphatidic acid -- PABD PA-binding domain -- PAP Phosphatidic acid phosphohydrolase -- PC Phosphatidylcholine -- PE Phosphatidylethanolamine -- PG Phosphatidylglycerol -- PI Phosphoinositides -- PLA Phospholipase A -- PLD Phospholipase D -- PS Phosphatidylserine -- TG Triglycerides; Cellular control mechanisms -- Periodicals; Biological control systems -- Periodicals; Molecular biology -- Periodicals; Periodicals; 571.74
• DOI: 10.1016/j.jbior.2020.100772
• Languages: English
• ISSNs: 2212-4926

Abstract

Abstract: Lipids have emerged as important actors in an ever-growing number of key functions in cell biology over the last few years. Among them, glycerophospholipids are major constituents of cellular membranes. Because of their amphiphilic nature, phospholipids form lipid bilayers that are particularly useful to isolate cellular content from the extracellular medium, but also to define intracellular compartments. Interestingly, phospholipids come in different flavors based on their fatty acyl chain composition. Indeed, lipidomic analyses have revealed the presence in cellular membranes of up to 50 different species of an individual class of phospholipid, opening the possibility of multiple functions for a single class of phospholipid. In this review we will focus on phosphatidic acid (PA), the simplest phospholipid, that plays both structural and signaling functions. Among the numerous roles that have been attributed to PA, a key regulatory role in secretion has been proposed in different cell models. We review here the evidences that support the idea that mono- and poly-unsaturated PA control distinct steps in hormone secretion from neuroendocrine cells.