[AU(DIEN)Cl]Cl2: Exchange Phenomena Observed by H1 and C13 NMR Spectroscopy. Issue 4 (1999)
- Record Type:
- Journal Article
- Title:
- [AU(DIEN)Cl]Cl2: Exchange Phenomena Observed by H1 and C13 NMR Spectroscopy. Issue 4 (1999)
- Main Title:
- [AU(DIEN)Cl]Cl2: Exchange Phenomena Observed by H1 and C13 NMR Spectroscopy
- Authors:
- Best Best, Sabine L. Sabine L.
Guo Guo, Zijian Zijian
Djuran Djuran, Milos I. Milos I.
Sadler Sadler, Peter J. Peter J. - Abstract:
- Abstract : The solution behaviour of the square-planar gold(III) complex [Au(dien)Cl]Cl 2 (dien = 1, 5- diamino-3-azapentane) was investigated by H 1 and C 13 NMR spectroscopy. We have found that H 1 NMR spectra of [Au(dien)Cl]Cl 2 are characterised by exchange behaviour over the whole pH range, and some exchange effects are also seen in C 13 NMR spectra of the deprotonated hydroxo derivative of the complex in alkaline solution. An exchange rate of > 378 s -1 was determined from H 1 NMR spectra at pH ∗ 2 (coalescence temperature 40 C ° ). In slightly acidic solutions of the complex, H 1 chemical shifts are in accordance with the known deprotonation of the central amine group of the complexed diethylenetriamine ligand. In C 13 NMR spectra, two separate sets of resonances are observed for the chloro and the hydroxo complex of gold(III) diethylenetriamine. The hydroxo complex [ Au ( dien-H ) OH ] + shows exchange effects in C 13 NMR spectra. Variable temperature studies show the carbon atoms next to the central secondary amine to be inequivalent and each present in two different environments that are in intermediate to fast exchange on the NMR time-scale.
- Is Part Of:
- Metal-based drugs. Volume 6:Issue 4/5(1999)
- Journal:
- Metal-based drugs
- Issue:
- Volume 6:Issue 4/5(1999)
- Issue Display:
- Volume 6, Issue 4/5 (1999)
- Year:
- 1999
- Volume:
- 6
- Issue:
- 4/5
- Issue Sort Value:
- 1999-0006-NaN-0000
- Page Start:
- 261
- Page End:
- 269
- Publication Date:
- 1999
- Subjects:
- Metals -- Therapeutic use -- Periodicals
Pharmaceutical chemistry -- Periodicals
Drugs -- Periodicals
Drugs
Metals -- Therapeutic use
Pharmaceutical chemistry
Chemistry, Pharmaceutical -- Periodicals
Metals -- therapeutic use -- Periodicals
Pharmaceutical Preparations -- Periodicals
Periodicals
Electronic journals
615.23 - Journal URLs:
- https://www.hindawi.com/journals/mbd/ ↗
- DOI:
- 10.1155/MBD.1999.261 ↗
- Languages:
- English
- ISSNs:
- 0793-0291
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 16215.xml