Differences in E-Cadherin and Syndecan-1 Expression in Different Types of Ameloblastomas. (23rd April 2018)

• Record Type: Journal Article
• Authors: Carreón-Burciaga, Ramón G.; González-González, Rogelio; Molina-Frechero, Nelly; López-Verdín, Sandra; Pereira-Prado, Vanesa; Bologna-Molina, Ronell
• Other Names: Amantini Consuelo Academic Editor.
• Is Part Of: Analytical cellular pathology. Volume 2018(2018)
• Publication Date: 2018-04-23
• Subjects: Pathology, Cellular -- Periodicals; Cytology -- Periodicals; Oncology -- Periodicals; Cancer -- Cytopathology -- Periodicals; Cancer -- Cytopathology; Cytology; Oncology; Pathology, Cellular; Cell Transformation, Neoplastic; Cells -- pathology; Cytological Techniques; Genetic Techniques; Periodicals; 571.936
• DOI: 10.1155/2018/9392632
• Languages: English
• ISSNs: 2210-7177

Abstract

Abstract : Ameloblastomas are a group of benign, locally aggressive, recurrent tumors characterized by their slow and infiltrative growth. E-Cadherin and syndecan-1 are cell adhesion molecules related to the behavior of various tumors, including ameloblastomas. Ninety-nine ameloblastoma samples were studied; the expression of E-cadherin and syndecan-1 were evaluated by immunohistochemistry. E-Cadherin and epithelial syndecan-1 were more highly expressed in intraluminal/luminal unicystic ameloblastoma than in mural unicystic ameloblastoma and solid/multicystic ameloblastoma, whereas the stromal expression of syndecan-1 was higher in mural unicystic ameloblastoma and solid/multicystic ameloblastoma. Synchronicity was observed between E-cadherin and epithelial syndecan-1; the expression was correlated with intensity in all cases. There was a strong association between expression and tumor size and recurrence. The evaluation of the expression of E-cadherin and syndecan-1 are important for determining the potential aggressiveness of ameloblastoma variants. Future studies are required to understand how the expression of these markers is related to tumor aggressiveness.