Effect of D614G Spike Variant on Immunoglobulin G, M, or A Spike Seroassay Performance. (1st December 2020) - Klumpp-Thomas, Carleen
Abstract: Emergence of a new spike protein variant (D614G) with increased infectivity has prompted many to analyze its role in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. There is concern regarding whether an individual exposed to one variant of a virus will have cross-reactive memory to the second variant. Accordingly, we analyzed the serologic reactivity of both variants, and we found that antibodies from 88 donors from a high-incidence population reacted toward both the original spike and the D614 spike variant. These data suggest that patients who are exposed to either variant have cross-responsive humoral immunity. This represents an important finding both for SARS-CoV-2 disease biology and for therapeutics. Abstract : As the D614G spike variant emerged as the main severe acute respiratory syndrome coronavirus 2 variant in the United States, concerns arose regarding possible differences in antibody binding and serologic assay performance. We show that antibodies cross-react with both variants.