Apelin and chemerin receptors are G protein-coupled receptors involved in metabolic as well as reproductive functions: Potential therapeutic implications?. (February 2021)

• Record Type: Journal Article
• Authors: Estienne, Anthony; Bongrani, Alice; Froment, Pascal; Dupont, Joëlle
• Is Part Of: Current opinion in endocrine and metabolic research. Volume 16(2021)
• Page Start: 86
• Page End: 95
• Publication Date: 2021-02
• Subjects: Apelin/APJ system -- Chemerin -- CMKLR1 -- GPR1 -- CCRL2 -- Metabolism -- Reproduction; Akt protein kinase B or PKB -- AMPK AMP-activated protein kinase -- α-NETA 2-(α-naphthoyl) ethyltrimethylammonium -- APELA/ELABELA/Toddler apelin receptor early endogenous ligand -- APJ apelin receptor -- APLN apelin -- AVP arginine vasopressin -- BAT brown adipose tissue -- cAMP cyclic adenosine monophosphate -- CCRL2 C–C motif chemokine receptor-like 2 -- CHO Chinese hamster ovary -- CMKLR1 chemokine-like receptor 1 -- ERK1/2 extracellular signal-regulated protein kinases 1 and 2 -- GPCRs G protein-coupled receptors -- GPR1 G protein-coupled receptor 1 -- HUVECs human umbilical vein endothelial cells -- IGF-1 insulin-like growth factor 1 -- IR insulin resistance -- MAPK mitogen-activated protein kinases -- NAFLD nonalcoholic fatty liver disease -- NK natural killer cells -- PCOS polycystic ovary syndrome -- PE preeclampsia -- PGF2α prostaglandin F2α -- PKA protein kinase A -- RARRES2 retinoic acid receptor responder protein 2 -- T2DM type 2 diabetes mellitus -- TIG2 tazarotene-induced gene 2 protein -- VSMCs vascular smooth muscle cells -- WAT white adipose tissue; Endocrine glands -- Diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; Endocrine System Diseases; Metabolic Diseases; Endocrine glands -- Diseases; Metabolism -- Disorders; Periodical; Electronic journals; Periodicals; Electronic journals; 616.4
• DOI: 10.1016/j.coemr.2020.09.005
• Languages: English
• ISSNs: 2451-9650

Abstract

Abstract: Adipokines are a large group of polypeptide hormones secreted by white adipose tissue able to interact through different receptors with several organs, including liver, central nervous system and gonads. In this review, we will focus on the adipokines that mediate their effects through G protein-coupled receptors, namely apelin and chemerin. Firstly, we will review their structure and that of their receptors (APJ for apelin, CMKLR1, GPR1 and CCRL2 for chemerin), as well as their tissue distribution and molecular mechanisms. In the second part of the review, we will focus more in detail on the known metabolic and reproductive effects of these receptors, in both physiological and pathological conditions, underlining their relevant potential clinical implications.