Metabolic and inflammatory functions of short-chain fatty acid receptors. (February 2021)

• Record Type: Journal Article
• Authors: Bolognini, Daniele; Dedeo, Domonkos; Milligan, Graeme
• Is Part Of: Current opinion in endocrine and metabolic research. Volume 16(2021)
• Page Start: 1
• Page End: 9
• Publication Date: 2021-02
• Subjects: Short-chain fatty acids -- G protein–coupled receptors -- FFA2 -- FFA3 -- Enteroendocrine -- Pancreas -- Immune cells; ALDH1A2 aldehyde dehydrogenase 1 family member -- BAFF B-cell activating factor -- CMTB 4-chloro-α-(1-methylethyl)-N-2-thiazolylbenzeneacetamide -- DREADD Designer Receptor Exclusively Activated by Designer Drug -- GSIS glucose-stimulated insulin secretion -- GLP-1 glucagon-like peptide 1 -- GTT glucose tolerance test -- HFD high-fat diet -- IgA immunoglobulin A -- IgG immunoglobulin G -- ILC3 type 3 innate lymphoid cell -- KO knock-out -- PA (S)-2-(4-chlorophenyl)-3, 3-dimethyl-N-(5-phenylthiazol-2-yl)butanamide -- PNS peripheral nervous system -- PYY peptide YY -- SCA small carboxylic acid -- SCFA short-chain fatty acid -- SCG superior cervical ganglion; Endocrine glands -- Diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; Endocrine System Diseases; Metabolic Diseases; Endocrine glands -- Diseases; Metabolism -- Disorders; Periodical; Electronic journals; Periodicals; Electronic journals; 616.4
• DOI: 10.1016/j.coemr.2020.06.005
• Languages: English
• ISSNs: 2451-9650

Abstract

Abstract: FFA2 and FFA3 are receptors for short-chain fatty acids which are produced in prodigious amounts by fermentation of poorly digested carbohydrates by gut bacteria. Understanding the roles of these receptors in regulating enteroendocrine, metabolic and immune functions has developed with the production and use of novel pharmacological tools and animal models. A complex (patho)physiological scenario is now emerging in which strategic expression of FFA2 and FFA3 in key cell types and selective modulation of their signalling might regulate body weight management, energy homoeostasis and inflammatory disorders.