Simian virus 40 transformation, malignant mesothelioma and brain tumors. (October 2011)

• Record Type: Journal Article
• Authors: Qi, Fang; Carbone, Michele; Yang, Haining; Gaudino, Giovanni
• Is Part Of: Expert review of respiratory medicine. Volume 5:Number 5(2010)
• Page Start: 683
• Page End: 697
• Publication Date: 2011-10
• Subjects: brain tumor -- malignant mesothelioma -- SV40 -- Tag -- tag -- transformation; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Diseases -- Treatment -- Periodicals; 616.2005
• DOI: 10.1586/ers.11.51
• Languages: English
• ISSNs: 1747-6348

Abstract

Simian virus 40 (SV40) is a DNA virus isolated in 1960 from contaminated polio vaccines, that induces mesotheliomas, lymphomas, brain and bone tumors, and sarcomas, including osteosarcomas, in hamsters. These same tumor types have been found to contain SV40 DNA and proteins in humans. Mesotheliomas and brain tumors are the two tumor types that have been most consistently associated with SV40, and the range of positivity has varied about from 6 to 60%, although a few reported 100% of positivity and a few reported 0%. It appears unlikely that SV40 infection alone is sufficient to cause human malignancy, as we did not observe an epidemic of cancers following the administration of SV40-contaminated vaccines. However, it seems possible that SV40 may act as a cofactor in the pathogenesis of some tumors. In vitro and animal experiments showing cocarcinogenicity between SV40 and asbestos support this hypothesis.