Developments in virus-like particle-based vaccines for infectious diseases and cancer. (November 2011)

• Record Type: Journal Article
• Authors: Buonaguro, Luigi; Tagliamonte, Maria; Tornesello, Maria Lina; Buonaguro, Franco M
• Is Part Of: Expert review of vaccines. Volume 10:Number 11(2011)
• Page Start: 1569
• Page End: 1583
• Publication Date: 2011-11
• Subjects: antigen presentation -- cancer -- infectious diseases -- vaccine -- virus-like particles; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1586/erv.11.135
• Languages: English
• ISSNs: 1476-0584

Abstract

Virus-like particles hold great promise for the development of effective and affordable vaccines. Indeed, virus-like particles are suitable for presentation and efficient delivery of linear as well as conformational antigens to antigen-presenting cells. This will ultimately result in optimal B-cell activation and cross-presentation with both MHC class I and II molecules to prime CD4 + T-helper as well as CD8 + cytotoxic T cells. This article provides an update on the development and use of virus-like particles as vaccine approaches for infectious diseases and cancer.