Effect of side chain phenyl group on the self‐assembled morphology of dipeptide hydrazides. Issue 2 (6th October 2020)

• Record Type: Journal Article
• Authors: Ohtomi, Taku; Higashi, Sayuri L.; Mori, Daisuke; Shibata, Aya; Kitamura, Yoshiaki; Ikeda, Masato
• Other Names: Chmielewski Jean guestEditor.
• Is Part Of: Peptide science. Volume 113:Issue 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-10-06
• Subjects: hydrazide -- hydrogel -- peptide -- self‐assembly; Peptides -- Periodicals; 572.6505
• DOI: 10.1002/pep2.24200
• Languages: English
• ISSNs: 2475-8817

Abstract

Abstract: We report self‐assembled nanostructures of dipeptides hydrazides, in which alanine and/or phenylalanine are employed as components to investigate the effect of the side chain phenyl group on the morphology of self‐assembled nanostructures. We demonstrated that the dimensions of the self‐assembled nanostructures can vary from 1D (fiber and tubular) to 2D (sheet) solely by adjusting the position of the side chain phenyl group in the simple molecular scaffold of the dipeptide hydrazides. This study highlights the significance and potential of systematic investigations for fine‐tuning the morphology of aqueous self‐assembled structures of the dipeptide hydrazides with the aim of exploring functional soft nanomaterials. Abstract :