Recent advances in non-specific immune memory against bovine tuberculosis. (April 2021)

• Record Type: Journal Article
• Authors: Blanco, F.C.; Sabio y Garcia, J.; Bigi, F.
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 75(2021)
• Publication Date: 2021-04
• Subjects: Bovine tuberculosis -- Innate immune response -- Trained immunity -- Gamma delta T cells; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2021.101615
• Languages: English
• ISSNs: 0147-9571

Abstract

Highlights: Mycobacterium bovis induces trained innate immunity in cattle. Cattle innate immune memory would involve epigenetic changes triggered by the NOD2-signalling pathway. γẟ T cells express memory markers and are involved in local and systemic immune response. Abstract: Bovine tuberculosis is an important worldwide disease mainly related to cattle, although it also affects other mammals, including humans. In recent years, there have been considerable advances in the knowledge of the immune response mechanisms underlying the interaction of Mycobacterium bovis, the main agent of bovine tuberculosis, with its hosts. In this review we describe the most recent findings on the cattle immune response to M. bovis, particularly regarding trained innate immune responses and γδ T cells, that could support the development of vaccines and diagnostic tools to control this disease.