Manganese-induced neurotoxicity: from C. elegans to humans. Issue 2 (24th November 2014)

• Record Type: Journal Article
• Authors: Chen, Pan; Chakraborty, Sudipta; Peres, Tanara V.; Bowman, Aaron B.; Aschner, Michael
• Is Part Of: Toxicology research. Volume 4:Issue 2(2015:Mar.)
• Page Start: 191
• Page End: 202
• Publication Date: 2014-11-24
• Subjects: Toxicology -- Periodicals; 615.9005
• DOI: 10.1039/c4tx00127c
• Languages: English
• ISSNs: 2045-452X

Abstract

Graphical Abstract: Abstract: Manganese (Mn) is one of the most abundant metals on the earth. It is required for normal cellular activities, but overexposure leads to toxicity. Neurons are more susceptible to Mn-induced toxicity than other cells, and accumulation of Mn in the brain results in Manganism that presents with Parkinson's disease (PD)-like symptoms. In the last decade, a number of Mn transporters have been identified, which improves our understanding of Mn transport in and out of cells. However, the mechanism of Mn-induced neurotoxicity is only partially uncovered, with further research needed to explore the whole picture of Mn-induced toxicity. In this review, we will address recent progress in Mn-induced neurotoxicity from C. elegans to humans, and explore future directions that will help understand the mechanisms of its neurotoxicity.