On the quantitative effects of compression of retinal fundus images on morphometric vascular measurements in VAMPIRE. (April 2021)

• Record Type: Journal Article
• Authors: Mookiah, Muthu Rama Krishnan; Hogg, Stephen; MacGillivray, Tom; Trucco, Emanuele
• Is Part Of: Computer methods and programs in biomedicine. Volume 202(2021)
• Publication Date: 2021-04
• Subjects: Retinal imaging -- JPEG Compression -- Retinal biomarkers -- VAMPIRE; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2021.105969
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: Effect of JPEG compression on morphometric vascular measurements were reported. Retinal vascular measurements were computed with VAMPIRE software. Agreement between measurements from compressed and uncompressed images were studied. Abstract: Background and Objectives: This paper reports a quantitative analysis of the effects of joint photographic experts group (JPEG) image compression of retinal fundus camera images on automatic vessel segmentation and on morphometric vascular measurements derived from it, including vessel width, tortuosity and fractal dimension. Methods: Measurements are computed with vascular assessment and measurement platform for images of the retina (VAMPIRE), a specialized software application adopted in many international studies on retinal biomarkers. For reproducibility, we use three public archives of fundus images (digital retinal images for vessel extraction (DRIVE), automated retinal image analyzer (ARIA), high-resolution fundus (HRF)). We generate compressed versions of original images in a range of representative levels. Results: We compare the resulting vessel segmentations with ground truth maps and morphological measurements of the vascular network with those obtained from the original (uncompressed) images. We assess the segmentation quality with sensitivity, specificity, accuracy, area under the curve and Dice coefficient. We assess the agreement between VAMPIRE measurements from compressed and uncompressed images with correlation, intra-class correlation and Bland-Altman analysis. Conclusions: Results suggest that VAMPIRE width-related measurements (central retinal artery equivalent (CRAE), central retinal vein equivalent (CRVE), arteriolar-venular width ratio (AVR)), the fractal dimension (FD) and arteriolar tortuosity have excellent agreement with those from the original images, remaining substantially stable even for strong loss of quality (20% of the original), suggesting the suitability of VAMPIRE in association studies with compressed images.