Development and characterization of electrospun curcumin-loaded antimicrobial nanofibrous membranes. Issue 13 (July 2021)

• Record Type: Journal Article
• Authors: Awan, Javeed A; Rehman, Saif Ur; Bangash, Muhammad Kashif; Ali, Usman; Asad, Muhammad; Hussain, Fiaz; Jaubert, Jean-Noël
• Is Part Of: Textile research journal. Volume 91:Issue 13/14(2021)
• Page Start: 1478
• Page End: 1485
• Publication Date: 2021-07
• Subjects: antimicrobial nanofibrous membrane -- curcumin -- electrospinning -- SEM -- FTIR -- Kirby Bauer disk diffusion test; Textile industry -- Periodicals; Textile fabrics -- Periodicals; Textile research -- Periodicals; Textiles et tissus -- Industrie et commerce -- Périodiques; Textiles et tissus -- Périodiques; Textiles et tissus -- Recherche -- Périodiques; Electronic journals; 677.005
• DOI: 10.1177/0040517520925514
• Languages: English
• ISSNs: 0040-5175

Abstract

Curcumin is a naturally occurring hydrophobic polyphenol compound. It exhibits a wide range of biological activities such as antibacterial, anti-inflammatory, anti-carcinogenic, antifungal, anti-HIV, and antimicrobial activity. In this research work, antimicrobial curcumin nanofibrous membranes are produce by an electrospinning technique using the Eudragit RS 100 (C19 H34 ClNO6 ) polymer solution enriched with curcumin. The morphology and chemistry of the membrane are analyzed using scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. Kirby Bauer disk diffusion tests are carried out to examine the antibacterial effectiveness of the membrane. Experimental results show that the nanofibers produced are of uniform thickness morphology and curcumin is successfully incorporated into the nanofibrous mat, while no chemical bonding was observed between curcumin and the polymer. The antimicrobial curcumin nanofibrous membranes can be effectively applied as antimicrobial barrier in a wide variety of medical applications such as wound healing, scaffolds, and tissue engineering.