Metal-free hydroalkoxylation of ynesulfonamides with esters. Issue 10 (18th February 2021)

• Record Type: Journal Article
• Authors: Gao, Erhui; Peng, Cheng; Zhang, Jingyi; Wang, Xiao-Na; Chang, Junbiao
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 10(2021)
• Page Start: 2182
• Page End: 2185
• Publication Date: 2021-02-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02575e
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A TMSOTf-catalyzed hydroalkoxylation of ynesulfonamides with esters is described for the efficient synthesis of alkoxy-substituted enamides with high stereoselectivity. Abstract : An efficient metal-free hydroalkoxylation reaction of ynesulfonamides with esters under mild conditions is described. Under the catalysis of TMSOTf, various ynesulfonamides are transformed into the corresponding alkoxy-substituted enamides in high yields with complete regioselectivity and high to excellent stereoselectivity.