Early use of continuous glucose monitoring in children and adolescents after total pancreatectomy with islet autotransplantation. Issue 3 (10th December 2020)

• Record Type: Journal Article
• Authors: McEachron, Kendall R.; Potlapalli, Neha; Rayannavar, Arpana; Downs, Elissa M.; Schwarzenberg, Sarah J.; Kirchner, Varvara A.; Beilman, Gregory J.; Chinnakotla, Srinath; Bellin, Melena D.
• Is Part Of: Pediatric diabetes. Volume 22:Issue 3(2021)
• Page Start: 434
• Page End: 438
• Publication Date: 2020-12-10
• Subjects: continuous glucose monitoring -- diabetes technology -- islet transplantation -- TPIAT; Diabetes in children -- Periodicals; 616.462
• DOI: 10.1111/pedi.13168
• Languages: English
• ISSNs: 1399-543X

Abstract

Abstract: Background: Children undergoing total pancreatectomy with islet autotransplantation (TPIAT) for chronic pancreatitis require intensive insulin therapy early after TPIAT with narrow glycemic targets, which can a present significant care burden. Outpatient use of continuous glucose monitoring (CGM) systems by children and caregivers early after TPIAT is inadequately studied. Methods: In this open‐label study, we randomized 14 children and adolescents (mean age 15.4 years) after hospital discharge for TPIAT to Dexcom G6 CGM ( n = 7) or standard care with a glucometer ( n = 7) to assess acceptability and glycemic control with use of CGM versus usual care (glucometer). Participants in the control arm also wore a blinded CGM for 1 week. Result: Children randomized to real‐time CGM had lower mean sensor glucose values compared with controls ( p = 0.002), and high overall satisfaction with CGM. Conclusions: Our data indicate that CGM is a useful adjunct to diabetes management for children who have recently undergone TPIAT.