Palladium-catalyzed direct alkynylation of thiophenes with halosilylacetylenes. (16th March 2021)

• Record Type: Journal Article
• Authors: Kato, Hayate; Tsukada, Naofumi
• Is Part Of: Tetrahedron letters. Volume 67(2021)
• Publication Date: 2021-03-16
• Subjects: Palladium -- Thiophene -- Alkyne -- Regioselective reaction -- CH functionalization; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.152869
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Palladium catalyzed alkynylation of thiophenes with halosilylacetylenes. Regioselective alkynylation of thiophenes. Transformation of a silylalkynyl substituent on thiophene. Abstract: Silylethynylthiophenes were obtained from palladium-catalyzed alkynylation of various thiophenes with 1-halo-2-silylacetylenes. The α-position of thiophenes was alkynylated with high regioselectivity. The terminal silyl groups of products could be replaced by several functional groups.