Domain adversarial networks and intensity-based data augmentation for male pelvic organ segmentation in cone beam CT. (April 2021)

• Record Type: Journal Article
• Authors: Brion, Eliott; Léger, Jean; Barragán-Montero, A.M.; Meert, Nicolas; Lee, John A.; Macq, Benoit
• Is Part Of: Computers in biology and medicine. Volume 131(2021)
• Publication Date: 2021-04
• Subjects: Deep learning -- Radiotherapy -- Unsupervised domain adaptation -- Segmentation; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2021.104269
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: In radiation therapy, a CT image is used to manually delineate the organs and plan the treatment. During the treatment, a cone beam CT (CBCT) is often acquired to monitor the anatomical modifications. For this purpose, automatic organ segmentation on CBCT is a crucial step. However, manual segmentations on CBCT are scarce, and models trained with CT data do not generalize well to CBCT images. We investigate adversarial networks and intensity-based data augmentation, two strategies leveraging large databases of annotated CTs to train neural networks for segmentation on CBCT. Adversarial networks consist of a 3D U-Net segmenter and a domain classifier. The proposed framework is aimed at encouraging the learning of filters producing more accurate segmentations on CBCT. Intensity-based data augmentation consists in modifying the training CT images to reduce the gap between CT and CBCT distributions. The proposed adversarial networks reach DSCs of 0.787, 0.447, and 0.660 for the bladder, rectum, and prostate respectively, which is an improvement over the DSCs of 0.749, 0.179, and 0.629 for "source only" training. Our brightness-based data augmentation reaches DSCs of 0.837, 0.701, and 0.734, which outperforms the morphons registration algorithms for the bladder (0.813) and rectum (0.653), while performing similarly on the prostate (0.731). The proposed adversarial training framework can be used for any segmentation application where training and test distributions differ. Our intensity-based data augmentation can be used for CBCT segmentation to help achieve the prescribed dose on target and lower the dose delivered to healthy organs. Highlights: Two strategies allow U-Net to segment CBCT, using annotations only for CT. Proposed domain adversarial networks apply the gradient reversal layer to U-Net. Proposed intensity-based data augmentations transform CT at the pixel level. Both approaches perform competitively with registration, while being faster.