In Situ Synthesis of Photoactive Polymers on a Living Cell Surface via Bio‐Palladium Catalysis for Modulating Biological Functions. (1st February 2021)

• Record Type: Journal Article
• Authors: Qi, Ruilian; Zhao, Hao; Zhou, Xin; Liu, Jian; Dai, Nan; Zeng, Yue; Zhang, Endong; Lv, Fengting; Huang, Yiming; Liu, Libing; Wang, Yilin; Wang, Shu
• Is Part Of: Angewandte Chemie. Volume 133:Number 11(2021)
• Page Start: 5823
• Page End: 5829
• Publication Date: 2021-02-01
• Subjects: bio-Pd catalysis -- cell activity regulation -- cell surface engineering -- in situ polymerization; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202015247
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Cell surface engineering with functional polymers is an effective strategy to modulate cell activity. Here, a bio‐palladium catalyzed polymerization strategy was developed for in situ synthesis of conjugated polymers on living cell surfaces. Through Sonagashira polymerization, photoactive polyphenyleneethynylene (PPE) is synthesized on the cell surface via cell‐generated bio‐Pd catalyst. The in situ formed PPE is identified by excellent light‐harvest capacity and blue fluorescence on the surfaces of E. coli and C. pyrenoidosa . Besides imaging microbes for tracing the polymerization process, PPE also exhibits enhanced antibacterial activity against E. coli . It can also augment the ATP synthesis of C. pyrenoidosa through enlarging the light absorption and accelerating the cyclic electron transport of the algae. With this bio‐metal catalyzed polymerization method, functional polymers can be synthesized in situ on the living cell surface. Abstract : An in situ polymerization strategy to modify cell surface with conjugated polymers was developed by a bio‐Pd nanoparticle catalyst on a cell surface. The in situ formed PPE traces the polymerization process, exhibits enhanced antibacterial activity against E. coli, and augments the ATP synthesis of C. pyrenoidosa .