The attentive focus on T cell‐mediated autoimmune pathogenesis of psoriasis, lichen planus and vitiligo. (25th November 2020)

• Record Type: Journal Article
• Authors: Aghamajidi, Azin; Raoufi, Ehsan; Parsamanesh, Gilda; Jalili, Ahmad; Salehi‐Shadkami, Mohammad; Mehrali, Marjan; Mohsenzadegan, Monireh
• Is Part Of: Scandinavian journal of immunology. Volume 93:Number 4(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-11-25
• Subjects: biologics -- Lichen planus -- psoriasis -- T cells -- vitiligo; Immunology -- Periodicals; 571.96
• DOI: 10.1111/sji.13000
• Languages: English
• ISSNs: 0300-9475

Abstract

Abstract: T cell‐mediated autoimmune skin diseases develop as a result of the aberrant immune response to the skin cells with T cells playing a central role. These chronic inflammatory skin diseases encompass various types including psoriasis, lichen planus and vitiligo. These diseases show similarities in their immune‐pathophysiology. In the last decade, immunomodulating agents have been very successful in the management of these diseases thanks to a better understanding of the pathophysiology. In this review, we will discuss the immunopathogenic mechanisms and highlight the role of T lymphocytes in psoriasis, lichen planus and vitiligo. This study could provide new insights into a better understanding of targeted therapeutic pathways and biological therapies.