Sulfinylation on Superoxide Dismutase 1 Cys111: Novel Mechanism for 1‐Nitropyrene to Promote Acute Reactive Oxygen Species Generation. Issue 3 (10th March 2021)

• Record Type: Journal Article
• Authors: Xie, Guangshan; Zhu, Lin; Zhang, Yanhao; Song, Yuanyuan; Zhang, Hongna; Yang, Zhu; Cai, Zongwei
• Is Part Of: Small structures. Volume 2:Issue 3(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-10
• Subjects: Chemistry -- Periodicals; Science -- Periodicals; Engineering -- Periodicals; 505
• DOI: 10.1002/sstr.202170007
• Languages: English
• ISSNs: 2688-4062

Abstract

Abstract : 1‐Nitropyrene In article number 2000123, Zongwei Cai and co‐workers show that 1‐nitropyrene inhibits superoxide dismutase 1 (SOD1) activity to increase intracellular reactive oxygen species (ROS) by forming cysteine sulfinylation on Cys111 of SOD1. Therefore, a novel mechanism of 1‐nitropyrene‐induced acute cytotoxicity and ROS production is proposed.