Colorectal cancer vaccines in clinical trials. (June 2011)

• Record Type: Journal Article
• Authors: Speetjens, Frank M; Zeestraten, Eliane CM; Kuppen, Peter JK; Melief, Cornelis JM; van der Burg, Sjoerd H
• Is Part Of: Expert review of vaccines. Volume 10:Number 6(2011)
• Page Start: 899
• Page End: 921
• Publication Date: 2011-06
• Subjects: cancer -- colon -- colorectal -- immune monitoring -- immunotherapy -- therapeutic -- vaccine; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1586/erv.11.63
• Languages: English
• ISSNs: 1476-0584

Abstract

This article elucidates current strategies of active immunotherapy for colorectal cancer patients with a focus on T-cell mediated immunotherapy. Poor prognosis of especially stage III and IV colorectal cancer patients emphasizes the need for advanced therapeutic intervention. Here, we refer to clinical trials using either tumor cell-derived vaccines or tumor antigen vaccines with a special interest on safety, induced immune responses, clinical benefit and efforts to improve the clinical impact of these vaccines in the context of colorectal cancer treatment.