Squamous Cell Carcinoma of Nasal Vestibule and Pyramid: Outcomes and Reconstructive Strategies. (2nd October 2020)

• Record Type: Journal Article
• Authors: Lambertoni, Alessia; Cherubino, Mario; Battaglia, Paolo; De Col, Alessia; Giovannardi, Marta; Antognoni, Paolo; Valdatta, Luigi; Karligkiotis, Apostolos; Bignami, Maurizio; Castelnuovo, Paolo; Turri‐Zanoni, Mario
• Is Part Of: Laryngoscope. Volume 131:Number 4(2021)
• Page Start: E1198
• Page End: E1208
• Publication Date: 2020-10-02
• Subjects: Nasal vestibule -- head and neck cancer -- nonmelanoma skin cancer -- squamous cell carcinoma -- nasal reconstruction; Otolaryngology -- Periodicals; 617.51005
• DOI: 10.1002/lary.29107
• Languages: English
• ISSNs: 0023-852X

Abstract

Abstract : Objectives: Squamous cell carcinoma of nasal vestibule and pyramid is rare, thus classification, treatment protocol, and indications for elective neck treatment are still controversial. Nasal reconstruction is challenging, as well, and prosthesis is still used. Study Design: Retrospective cohort study. Methods: Retrospective review of patients surgically treated from 2010 to 2018 in a single Institution. Advanced tumors were further treated with adjuvant irradiation. Reconstruction strategy included grafts, locoregional and free flaps, and was customized on layers removed. Results: Forty‐five patients were enrolled. The 5‐year overall survival and disease‐free survival were 81.9% ± 7.45% and 61.9% ± 9.09%, respectively. Wang's classification, site of origin, extent of surgery and margins status significantly correlated with prognosis and recurrence rate. Regional recurrences occurred in patients affected by advanced tumors who did not receive any form of elective neck treatment. Conclusion: Multidisciplinary management and a proper reconstructive algorithm are recommended. Adjuvant irradiation and elective neck treatment should be advocated for advanced stage high‐risk patients. Level of Evidence: 4. Laryngoscope, 131:E1198–E1208, 2021