A Novel Homozygous VPS11 Variant May Cause Generalized Dystonia. Issue 4 (2nd February 2021)

• Record Type: Journal Article
• Authors: Monfrini, Edoardo; Cogiamanian, Filippo; Salani, Sabrina; Straniero, Letizia; Fagiolari, Gigliola; Garbellini, Manuela; Carsana, Emma; Borellini, Linda; Biella, Fabio; Moggio, Maurizio; Bresolin, Nereo; Corti, Stefania; Duga, Stefano; Comi, Giacomo P.; Aureli, Massimo; Di Fonzo, Alessio
• Is Part Of: Annals of neurology. Volume 89:Issue 4(2021)
• Page Start: 834
• Page End: 839
• Publication Date: 2021-02-02
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.26021
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : In this work, we describe the association of a novel homozygous VPS11 variant with adult‐onset generalized dystonia, providing a detailed clinical report and biological evidence of disease mechanism. Vps11 is a subunit of the homotypic fusion and protein sorting (HOPS) complex, which promotes the fusion of late endosomes and autophagosomes with the lysosome. Functional studies on mutated fibroblasts showed marked lysosomal and autophagic abnormalities, which improved after overexpression of the wild type Vps11 protein. In conclusion, a deleterious VPS11 variant, damaging the autophagic and lysosomal pathways, is the probable genetic cause of a novel form of generalized dystonia. ANN NEUROL 2021;89:834–839