The Hippo pathway: Horizons for innovative treatments of peripheral nerve diseases. Issue 1 (23rd January 2021)

• Record Type: Journal Article
• Authors: Feltri, M. Laura; Weaver, Michael R.; Belin, Sophie; Poitelon, Yannick
• Is Part Of: Journal of the peripheral nervous system. Volume 26:Issue 1(2021)
• Page Start: 4
• Page End: 16
• Publication Date: 2021-01-23
• Subjects: Hippo -- nerve injury and regeneration -- neurofibromatosis -- peripheral neuropathy -- schwann cell -- YAP/TAZ; Nervous system -- Periodicals; Nerves, Peripheral -- Diseases -- Periodicals; Peripheral Nervous System Diseases -- Periodicals; Peripheral Nervous System -- Periodicals; 612.81
• DOI: 10.1111/jns.12431
• Languages: English
• ISSNs: 1085-9489

Abstract

Abstract: Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to their environment by controlling proliferation, migration and differentiation. Many recent studies have focused on characterizing Hippo pathway function and regulation in mammalian cells. Here, we present a brief overview of the major components of the Hippo pathway, as well as their regulation and function. We comprehensively review the studies that have contributed to our understanding of the Hippo pathway in the function of the peripheral nervous system and in peripheral nerve diseases. Finally, we discuss innovative approaches that aim to modulate Hippo pathway components in diseases of the peripheral nervous system.