Comparative prognostic value of different preoperative complete blood count cell ratios in patients with oral cavity cancer treated with surgery and postoperative radiotherapy. (23rd February 2021)

• Record Type: Journal Article
• Authors: Wu, Yao‐Yu; Chang, Kai‐Ping; Ho, Tsung‐Ying; Chou, Wen‐Chi; Hung, Sheng‐Ping; Fan, Kang‐Hsing; Chiang, Yin‐Yin; Chou, Yung‐Chih; Tsang, Ngan‐Ming
• Is Part Of: Cancer medicine. Volume 10:Number 6(2021)
• Page Start: 1975
• Page End: 1988
• Publication Date: 2021-02-23
• Subjects: distant metastasis -- lymphocyte‐to‐monocyte ratio -- neutrophil‐to‐lymphocyte ratio -- oral cavity squamous cell carcinoma -- overall survival -- platelet‐to‐lymphocyte ratio; 616.994005
• DOI: 10.1002/cam4.3738
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Background: We sought to compare the prognostic significance of different preoperative complete blood count cell ratios in patients with oral cavity squamous cell carcinoma (OSCC) treated with surgery and postoperative radiotherapy (PORT). Methods: We retrospectively reviewed the clinical records of 890 patients with OSCC who were treated with surgery and PORT. The following preoperative complete blood count cell ratios were collected: neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR). Overall survival (OS), local control, regional control, and distant control (DC) served as the main outcomes of interest. Results: The results of multivariate analysis in the entire study cohort revealed that a low NLR was the only independently favorable marker of both OS (adjusted hazard ratio [HR]: 0.794, 95% confidence interval (CI): 0.656–0.961, bootstrap p = 0.028) and DC (adjusted HR: 0.659, 95% CI: 0.478–0.909, bootstrap p = 0.015). Both LMR and PLR were not retained in the model as independent predictors. Subgroup analyses in high‐risk patients (i.e., those bearing T4 disease, N3 disease, or poor differentiation) revealed that a high NLR was a significant adverse risk factor for both OS and DC (all p < 0.03)—with a borderline significance being evident for DC in patients with T4 disease ( p = 0.058). Conclusions: A high pretreatment NLR was an independent unfavorable risk factor for both OS and DC in patients with OSCC who underwent surgery and PORT. No other preoperative complete blood count parameters and cell ratios were found to have prognostic significance. Abstract : This relatively large cohort reports a comparative result: pretreatment high neutrophil‐to‐lymphocyte ratio (NLR) was an independent unfavorable risk factor for both overall survival and distant metastasis in patients with oral cavity squamous cell carcinoma (OSCC) who underwent surgery and postoperative radiotherapy. Lymphocyte‐to‐monocyte ratio (LMR) and platelet‐to‐lymphocyte ratio (PLR) were not significant.