Clinical benefit of neoadjuvant anti‐PD‐1/PD‐L1 utilization among different tumors. Issue 1 (11th March 2021)

• Record Type: Journal Article
• Authors: Li, Zhiyang; Wu, Xin; Zhao, Yanjie; Xiao, Yinan; Zhao, Yunuo; Zhang, Ting; Li, Hui; Sha, Fushen; Wang, Yating; Deng, Lei; Ma, Xuelei
• Is Part Of: MedComm. Volume 2:Issue 1(2021)
• Page Start: 60
• Page End: 68
• Publication Date: 2021-03-11
• Subjects: atezolizumab -- lung cancer -- neoadjuavant therapy -- PD‐1/PD‐L1 inhibitors -- triple‐negative breast cancer; 610
• DOI: 10.1002/mco2.61
• Languages: English
• ISSNs: 2688-2663

Abstract

Abstract: PD‐1/PD‐L1 (programmed cell death‐1 and programmed death‐ligand 1) inhibitors utilization in neoadjuvant therapy has been assessed in tumors. This study focused on the clinical benefits of neoadjuvant anti‐PD‐1/PD‐L1 therapy. A comprehensive search was conducted in electronic databases to identify eligible studies. Major response rate (MRR) and complete response rate (CRR) were pooled in this analysis to assess the efficacy of neoadjuvant anti‐PD‐1/PD‐L1 utilization, all grades and high‐grade adverse events (AEs) were pooled to evaluate its safety. Twenty studies were included in this meta‐analysis, with 828 patients suffering from different tumors. The pooled CRR of triple‐negative breast cancer was 0.569 (95% CI 0.514, 0.624, I 2 = 0%) and the pooled MRR of lung cancer was 0.471 (95% CI 0.267, 0.575, I 2 = 0%). The most frequent adverse event was fatigue (0.272 95% CI 0.171, 0.402, I 2 = 87%), and the most common high‐grade adverse event was febrile neutropenia (0.084 95% CI 0.063, 0.112, I 2 = 85%). In conclusion, neoadjuvant anti‐PD‐1/PD‐L1 therapy received satisfactory clinical results in these tumors included. Abstract : Twenty studies were included in this meta‐analysis. The pooled CRR of triple‐negative breast cancer and urothelial carcinoma was 0.569 (95% CI 0.514, 0.624) and 0.320 (95% CI 0.234, 0.407), respectively. The pooled MRR of lung cancer was 0.471 (95% CI 0.367, 0.575). In conclusion, neoadjuvant anti‐PD‐1/PD‐L1 therapy received satisfactory clinical results in these tumors.