Cyclodesulfurization: An Enabling Protocol for Synthesis of Various Heterocycles. Issue 10 (10th March 2021)

• Record Type: Journal Article
• Authors: Kadagathur, Manasa; Shaikh, Arbaz Sujat; Jadhav, Govinda Shivaji; Sigalapalli, Dilep Kumar; Shankaraiah, Nagula; Tangellamudi, Neelima D.
• Is Part Of: ChemistrySelect. Volume 6:Issue 10(2021)
• Page Start: 2621
• Page End: 2640
• Publication Date: 2021-03-10
• Subjects: Cyclodesulfurization -- Cyclization -- Desulfurization -- Isothiocyanates -- Thioureas.; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202100201
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: Heterocycles closely intertwine chemistry with biology reflecting the presence of nitrogen‐based heterocyclic ring structure in nearly 75 % of small‐molecule drugs. The number of reported strategies for the synthesis of several "privileged scaffolds" has expanded, amongst which, cyclodesulfurization of thioureas offers a quick access to highly substituted heterocycles, thereby playing a role of an excellent tool in organic syntheses of natural products and pharmaceutically active compounds. This comprehensive review emphasizes the applications of cyclodesulfurization as an integral synthetic step in the synthesis of nitrogen, oxygen and sulfur‐containing heterocycles. Furthermore, a survey of cyclodesulfurizing agents reported since 2000 is comprehensively reviewed and summarized. Abstract : Cyclodesulfurization is a quick and efficient strategy to construct highly substituted N ‐, O ‐ and S ‐containing heterocycles. This review focuses on the advancements in the development of various cyclodesulfurizing agents utilized in the fabrication of pharmaceutically relevant chemical entities.