A DNA nanosensor for monitoring ligand-induced i-motif formation. Issue 9 (18th February 2021)

• Record Type: Journal Article
• Authors: Saha, Puja; Panda, Deepanjan; Paul, Raj; Dash, Jyotirmayee
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 9(2021)
• Page Start: 1965
• Page End: 1969
• Publication Date: 2021-02-18
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob00248a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A GNP-based DNA nanosensor has been developed that identifies i-motif inducing ligands at physiological pH from a chemical library. Abstract : Herein, we present a gold nanoparticle (GNP)-based DNA nanosensor to detect the formation of an i-motif from the random coil structure by small molecules at physiological pH. The nanosensor shows a distance dependent fluorescence turn-off response in the presence of a ligand, indicating conformational changes from the C-rich single stranded DNA into an i-motif.