Aqueous chemoenzymatic one-pot enantioselective synthesis of tertiary α-aryl cycloketones via Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation. Issue 5 (25th February 2021)

• Record Type: Journal Article
• Authors: Luan, Pengqian; Liu, Yunting; Li, Yongxing; Chen, Ran; Huang, Chen; Gao, Jing; Hollmann, Frank; Jiang, Yanjun
• Is Part Of: Green chemistry. Volume 23:Issue 5(2021)
• Page Start: 1960
• Page End: 1964
• Publication Date: 2021-02-25
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc00372k
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : Aqueous chemoenzymatic two-step one-pot enantioselective synthesis of tertiary α-aryl cycloketones via Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation was developed. Abstract : An aqueous chemoenzymatic cascade reaction combining Pd-catalyzed C–C formation and enzymatic CC asymmetric hydrogenation (AH) was developed for enantioselective synthesis of tertiary α-aryl cycloketones in good yields and excellent enantioselectivities. The stereopreference of the enzyme in AH of α-aryl cyclohexenones was studied. An enantiocomplementary enzyme was obtained by site-directed mutation.