A novel ruthenium polypyridyl complex for the selective imaging and photodynamic targeting of the Golgi apparatus. Issue 10 (18th February 2021)

• Record Type: Journal Article
• Authors: Zhao, Fengyi; Wang, Weifan; Wu, Wenlong
• Is Part Of: Dalton transactions. Volume 50:Issue 10(2021)
• Page Start: 3536
• Page End: 3541
• Publication Date: 2021-02-18
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt00216c
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : An excellent example for the ruthenium(ii ) complex to lable the Golgi apparatus in vitro with significant photodynamic therapy. Abstract : A well-designed heteroleptic ruthenium(ii ) polypyridyl complex demonstrated stable target-specific in vitro Golgi apparatus imaging abilities in HeLa cell lines. After utilizing photodynamic therapy via UV excitation, the Ru–SL complex could be triggered to generate singlet oxygen ( 1 O2 ) and red fluorescence signals. 1 O2 was highly cytotoxic and could induce DNA damage and the disappearance of the Golgi apparatus. The red fluorescence signals disappeared gradually, suggesting that the live or dead state of the cells can be estimated from the fluorescence signal intensity.