Mesoporous silica-coated gold nanorods loaded with tetrazolyl phthalocyanine as NIR light-activated nano-switches for synergistic photothermal and photodynamic inactivation of antibiotic-resistant Escherichia coli. Issue 5 (15th February 2021)

• Record Type: Journal Article
• Authors: Ye, Qiuhao; Xiao, Shuanghuang; Lin, Ting; Jiang, Yufeng; Peng, Yiru; Huang, Yide
• Is Part Of: Materials advances. Volume 2:Issue 5(2021)
• Page Start: 1695
• Page End: 1705
• Publication Date: 2021-02-15
• Subjects: 620.11
• DOI: 10.1039/d0ma00782j
• Languages: English
• ISSNs: 2633-5409

Abstract

Abstract : A light-controlled nano-switch was assembled by mesoporous silica-coated gold nanorods with tetrazolyl phthalocyanines. This nano-switch exhibited synergistic photothermal and photodynamic inactivation of antibiotic-resistant Escherichia coli . Abstract : A light-controlled nano-switch was prepared by assembling mesoporous silica-coated gold nanorods with bis-(1-(4-hydroxyphenyl)-5-mercapto-tetrazolyl) silicon(iv ) phthalocyanines, which exhibited excellent triple functions with controlled release of phthalocyanines and generation of reactive oxygen species (ROS) as well as temperature enhancement under laser irradiation. The nano-switch achieved an effective antimicrobial activity against a variety of antibiotic-resistant Escherichia coli strains through synergistic photodynamic therapy and photothermal therapy by damaging the genomic DNA and enzyme activity of bacteria.