The reaction of prop-2-ynylsulfonium salts and sulfonyl-protected β-amino ketones to epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles. Issue 21 (15th February 2021)

• Record Type: Journal Article
• Authors: Jia, Tingting; Zeng, Gongruixue; Zhang, Chong; Zeng, Linghui; Zheng, Wenya; Li, Siyao; Wu, Keyi; Shao, Jiaan; Zhang, Jiankang; Zhu, Huajian
• Is Part Of: Chemical communications. Volume 57:Issue 21(2021)
• Page Start: 2657
• Page End: 2660
• Publication Date: 2021-02-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d0cc07745c
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A divergent domino reaction of prop-2-ynylsulfonium salts with sulfonyl-protected β-amino ketones was developed to afford epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles. Abstract : A novel divergent domino annulation reaction of prop-2-ynylsulfonium salts with sulfonyl-protected β-amino ketones has been developed, affording various epoxide-fused 2-methylenepyrrolidines and S-containing pyrroles in moderate to excellent yields. Prop-2-ynylsulfonium salts act as C2 synthons in the reactions providing a promising epoxide-fused skeleton in a single operation with readily accessible starting materials.